Back mutations, restoring critical non-human residues to retain binding affinity. Computational modeling and in silico tools to predict stability, reduce immunogenic epitopes, and optimize sequences.

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Antibodies play a vital role in the immune system by providing protection against foreign invaders, such as bacteria and viruses. Produced by B cells, antibodies are protein molecules that can be ...

In therapeutic applications, monoclonal antibodies (mAbs) provide highly precise targeting of pathological cells and reduced side effects in treating disease. Experimental mice are widely used models ...

The human anti-mouse antibody (HAMA) reaction limits the therapeutic utility of mouse monoclonal antibodies. Humanization of mouse monoclonal antibodies by genetic engineering can improve the in-vivo ...

The agreement grants Acepodia an option to obtain an exclusive worldwide license from Biocytogen for two BsADC programs. Under the terms of the agreement, Biocytogen is eligible to receive an upfront ...

The "Antibody Humanization and Affinity Maturation: Services and Platforms, 2017-2030" report has been added to Research and Markets' offering. The "Antibody Humanization and Affinity Maturation: ...

AbolerIS Pharma ("AbolerIS"), a clinical-stage biopharmaceutical company committed to improving the lives of people suffering from autoimmune and inflammatory diseases, announced today that the first ...

Due to advancements in genetic engineering, small animal models are continuing to change in response to market needs. Model developers strive to better reflect the role of this important asset in both ...

Antibody humanization and affinity maturation have revolutionized the biotech industry in the past 10–20 years, enabling the development of highly effective therapeutic antibodies that can be used to ...