For patients with brain metastases, treatment with an antibody-drug conjugate (ADC) at the same time as stereotactic radiotherapy significantly raises the risk of symptomatic radiation necrosis, a new ...

Immune checkpoint inhibitors and stereotactic radiosurgery do not increase the risk of necrosis among patients with NSCLC who have brain metastases, according to research. Treatment with immunotherapy ...

To better understand the spatiotemporal course of radiation-induced central nervous system (CNS) vascular necrosis and assess the therapeutic potential of approaches for protecting against ...

"SRS is generally very well tolerated, but if we do see a delayed complication from treatment, it is most commonly radionecrosis," said Trevor Royce, MD, MS, MPH, assistant professor in the Department ...

Radiation-induced brain injury (RIBI) is a serious and often delayed complication of cranial radiotherapy, which remains a cornerstone in the treatment of brain tumors such as gliomas, metastases, and ...

Radiotherapy induces DNA damage and oxidative stress, leading to endothelial injury and blood-brain barrier disruption, which triggers neuroinflammation, microvascular dysfunction, and neuronal ...

TORONTO, Dec. 8 2025 — While targeted radiation can be an effective treatment for brain tumours, subsequent potential necrosis of the treated areas can be hard to distinguish from the tumours on a ...

Radiotherapy (RT) to bulky (B) and extralymphatic (E) disease in combination with 6xR-CHOP-14 or R-CHOP-21 in young good-prognosis DLBCL patients: Results of the 2x2 randomized UNFOLDER trial of the ...

White blood cells are part of many immune system responses in the human body. New research shows that a specific type of those cells may cause brain cancer tissues to die – but that's not good news, ...