Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these advantages, protein-reactive compounds are ...

Covalent is a trusted provider of advanced measurement, analysis, and material characterization solutions supporting innovation and manufacturing excellence across high technology industries. Formerly ...

When most small-molecule drugs meet a protein target, they nestle close to their intended. But the flirtatious relationship between drug and target is often fleeting, with the drug repeatedly drifting ...

One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent bonds with their ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

Chemical bonding is the force of attraction that holds atoms together to form molecules or compounds. There are two primary types of chemical bonds: ionic and covalent bonds. Both these bonds play a ...

Researchers compared three different drug delivery models based on ionic liquids. Scientists have developed a powerful API-IL concept to access structural diversity and dual-action pharmaceuticals.

Researchers have developed a hybrid material by integrating bipyramid-shaped gold nanocrystals with sharp edge with a ...