Here, we summarize the cellular sources of IL-9, focusing principally on T cells. We also describe the main targets of IL-9 in vivo and discuss the downstream effects of IL-9-induced signalling on ...

Lung cancer is the leading cause of cancer-related death in industrialised countries. The majority of patients with lung cancer have incurable advanced disease with very poor therapeutic options, so ...

We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin-10 signaling.

Natural killer (NK) cells engineered to express interleukin-21 (IL-21) demonstrated sustained antitumor activity against glioblastoma stem cell-like cells (GSCs) both in vitro and in vivo, according ...

Interleukin-6 (IL-6), a versatile cytokine, plays a pivotal role in immune regulation, inflammatory responses, as well as cell proliferation and differentiation. Produced by a range of cell types ...

NEW YORK — Already in late-stage clinical trials, temtokibart, an interleukin (IL)-22 inhibitor, has demonstrated broad activity against multiple markers of inflammation, pruritus, and impaired ...

THURSDAY, March 21, 2024 (HealthDay News) -- Neutralizing anti-interleukin-23 is associated with severe, persistent, opportunistic infections, according to a study published in the March 21 issue of ...