DUNDEE, SCOTLAND — In a trial conducted in three European countries, switching arthritis patients with no known cardiovascular disease from conventional nonsteroidal anti-inflammatory drugs (NSAIDs) ...

Avoid NSAIDs because of dose-related increase in MACE, even when used for short durations If NSAIDs are medically necessary, educate patients about risks Nonselective NSAIDs are preferable Use ...

The Annals of Pharmacotherapy. 2006;40(6):1052-1063. Although the evidence of increased cardiovascular risk with certain coxibs is compelling compared with findings shown with placebo, the evidence is ...

Cyclo-oxygenase 2 (COX2) inhibitors were developed to provide pain relief without the gastrointestinal side effects associated with nonsteroidal anti-inflammatory drugs (NSAIDs); however, trial data ...

Patients with gastroesophageal reflux disease who are compliant with proton pump inhibitor therapy stay on NSAIDs longer than noncompliant patients. Study subjects were GERD patients receiving ...

Traditional nonselective NSAIDs are commonly prescribed to relieve symptoms of pain and inflammation, and have been favored over cyclo-oxygenase (COX) 2 inhibitors because of the increased risk of ...

Regular use of nonsteroidal anti-inflammatory drugs such as celecoxib and naproxen may increase the risk for CV events among postmenopausal women, according to a new report. Researchers observed a ...

Cyclooxygenase-2 (COX-2) inhibitors are a group of nonsteroidal anti-inflammatory drugs (NSAIDs) that may reduce the incidence of gastrointestinal side effects associated with nonselective NSAIDs.1, 2 ...

THE LAUNCH OF THE CYCLOOXYGENASE-2 (COX-2) selective NSAIDs was based on 2 hypotheses: (1) the major adverse effects limiting the usefulness of nonselective NSAIDs are gastrointestinal in nature and ...

Researchers have published the most comprehensive analyses of the benefits and risks of non-steroidal anti-inflammatory drugs (NSAIDs), which include cyclo-oxygenase-2 inhibitors (coxibs). The ...

Non-steroidal anti-inflammatory drugs (NSAIDs) and steroids (see Corticosteroid Therapy) can be useful for acute pain relief in patients with rheumatoid arthritis (RA). In osteoarthritis, studies have ...

stomach gastro Combining COX-2 inhibitors with PPIs may provide the best gastrointestinal protection to prevent NSAID-associated GI toxicity, study authors concluded in a meta-analysis published in ...