One could make the bold argument that Family Guy is a rip-off of The Simpsons, but despite both having a clownish, large father figure as the head of a dysfunctional family, it's not an entirely fair ...
Family Guy was transparently conceived as a Simpsons copycat, and it ripped off a lot of specific characters, both major and minor. Both shows have joked about Family Guy borrowing from The Simpsons.