Atherosclerosis is a lipid-driven chronic inflammatory disease that is modulated by innate and adaptive immunity including humoral immunity. Importantly, antibody alterations achieved by genetic means ...

ADCs integrate monoclonal antibodies with cytotoxic payloads, offering new treatment options for NSCLC, including biomarker-selected and biomarker-agnostic patients. ADCs are composed of an antibody, ...

Therapeutic antibodies, especially polyclonal antibodies, are indispensable in contemporary medicine for addressing a broad spectrum of conditions, including infectious diseases, autoimmune disorders, ...

The engineering and functional characterization of the Fc domain are key to therapeutic antibodies’ efficacy, safety, and pharmacokinetics. The Fc domain is responsible for mediating interactions with ...

ObjectivesThe aim of the present study was to compare the differences in clinical outcomes within 6 months postoperatively between a complement-dependent cytotoxicity <10% group of low-risk kidney ...

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

The dependent exemption tax credit, up to $300, may be claimed for each qualifying child and dependent of the taxpayer for whom the federal child tax credit under Internal Revenue Code, Section 24 was ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. FcγRI plays a crucial role in the effector function of IgG antibodies, interacting ...

B-cell depletion therapy (BCDT) has been employed to treat autoimmune disease for ~20 years. Immunoglobulin G1 (IgG1) monoclonal antibodies targeting CD20 and utilizing effector function (eg, antibody ...