Sodium valproate acutely inhibits lamotrigine metabolism - PMC
Abstract Concomitant administration of sodium valproate (VPA) reduced lamotrigine (LTG) total clearance by approximately 21% and increased elimination half-life and AUC. Reduced elimination …
Why does valproate increase lamotrigine levels? Explained
Nov 19, 2025 · Learn why valproate increases lamotrigine levels by inhibiting its primary metabolic pathway (glucuronidation), significantly raising the risk of skin rashes. This guide explains the …
Valproic Acid and Lamotrigine Interaction: Clinical Significance and ...
The interaction between valproic acid and lamotrigine occurs through inhibition of hepatic metabolism. Valproic acid inhibits UDP-glucuronosyltransferase (UGT) enzymes, particularly UGT1A4, which is …
IN VITRO CHARACTERIZATION OF LAMOTRIGINE N2-GLUCURONIDATION …
Studies were performed to investigate the UDP-glucuronosyltransferase enzyme(s) responsible for the human liver microsomal N2-glucuronidation of the anticonvulsant drug lamotrigine (LTG) and the …
Time course of reversal of valproate-mediated inhibition of lamotrigine
Apr 1, 2018 · UGT2B7 metabolizes a number of substrates, and is responsible for the phase II metabolism of a number of drugs and endogenous hormones. Both UGT1A4 and UGT2B7 catalyze …
Sodium valproate acutely inhibits lamotrigine metabolism
Abstract Concomitant administration of sodium valproate (VPA) reduced lamotrigine (LTG) total clearance by approximately 21% and increased elimination half-life and AUC. Reduced elimination …
Concomitant administration of sodium valproate (VPA) reduced lamotrigine (LTG) total clearance by approximately 21% and increased elimination half-life and AUC. Reduced elimination occurred …
Delirium From Valproic Acid With Lamotrigine
Jun 1, 2004 · The addition of valproic acid to a lamotrigine regimen interferes with or decreases metabolism by decreasing hepatic glucuronidation of lamotrigine and therefore increasing the …
Does valproate affect lamotrigine? A Pharmacological Guide
Nov 23, 2025 · The significant interaction between valproate and lamotrigine is a prime example of pharmacokinetic drug interaction, where one drug affects how the body processes another. …
Valproic Acid and Lamotrigine Interaction: Clinical Risks and ...
Valproic acid inhibits glucuronidation enzymes, particularly UDP-glucuronosyltransferases (UGTs), which are responsible for lamotrigine metabolism. This inhibition significantly reduces lamotrigine …