vcclab.org. Overview of the many logP and other physical property calculators available commercially and on-line. XLOGP3, a simple LogP estimator used by PubChem (release 2021.05.07)

Nov 17, 2025 · LogP and logD are important values to consider during drug design as both give insight to the lipophilicity and hydrophilicity of compounds.

LogP is the log of the partition coefficient of a solute between octanol and water, at near infinite dilution. LogP is widely used in drug discovery and development as an indicator of potential utility of a solute …

Jan 6, 2024 · LogP measures the logarithm of ration between the concentration of a compound in a non-polar solvent and in water. It is common practice to measure this using octanol (PubChem 2003) as …

LogP is widely used in cheminformatics and is a component of Lipinski’s “rule of five”, which is a golden standard to evaluate a drug-likeness of a compound. According to this rule, the successful drug …

Introduction Symbols Definition of Partition Coefficient P and Distribution Coefficient D Micro Partition Coefficient Relation Between Macro and Micro Partition Coefficients LogP calculation methods …

Examples for logP and logD calculations The following examples show log P /log D results for special molecules types. The calculations were performed with the default settings of the log P plugin. …

Due to the importance of the drug lipophilicity, logP is a component of the Lipinski rule of five. 1 LogP is defined as the partition coefficient of a molecule between aqueous and lipophilic phases usually …

LogP therefore provides a measure of the lipophilicity of a molecule. Lipophilicity is a key characteristic of drug molecules, affecting their absorption, distribution, metabolism and excretion (ADME). High …

Sep 3, 2022 · LogP gives you an indication of how well the molecule will partition into the organic elution solvent. The higher the logP, the more likely the compound will partition from the SLE phase into the …